:

"The latest breakthrough in chocolate research comes from Emmanualle di Tomaso et al. who have found that chocolate contains pharmacologically active substances that mimic the effects of marijuana on the brain (Di Tomasso et al. 1996). The pursuit of this line of research came from the observations that chocolate cravings were associated with psychoses induced by

certain drugs, such as MDMA (Chianese 1992; Di Tomasso et al. 1996). This suggested that chocolate cravings and effects are more than a sensory experience of the nervous system they involve some sort of pharmacologically active substance. Even though earlier research had focused on methylxanthines (caffeine and theobromine), these scientists focused on another substance, anandamide. Anandamide is a member of a family of fatty acid ethanolamides composed of arachidonic acid coupled to ethanolamine through an amide linkage (Devane et al.

1992).

Within the last couple of years, anandamide has been recognized as an endogenous cannabimimetic, meaning that it a substance produced in the body that binds to cannabinoid receptors with high affinity and mimics the effects of plant-derived cannabinoids on established

behavioral patterns (Di Tomasso et al. 1996; Axelrod and Felder 1998). Anandamide is not a classical neurotransmitter in the sense that its hydrophobicity allows it to easily pass through plasma membranes limiting its ability to be stored in synaptic vesicles. Instead, it may be synthesized when needed at the plasma membrane (Axelrod and Felder 1998). The cannabinoid "